Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …

Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two
species of mitochondrial (mt-) tRNAs encoded in mtDNA translate essential subunits of the …

Mitoribosomes are essential for the synthesis and maintenance of bioenergetic proteins.
Here we use cryo-electron microscopy to determine a series of the small mitoribosomal …

Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are
present in almost all eukaryotic organisms, including humans. They are the key energy …

The uridine modifications pseudouridine (Ψ), dihydrouridine, and 5-methyluridine are
present in eukaryotic mRNAs. Many uridine-modifying enzymes are associated with human …

ABSTRACT RNA species play host to a plethora of post-transcriptional modifications which
together make up the epitranscriptome. 5-methyluridine (m5U) is one of the most common …

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize a small subset of proteins,
which are essential components of the oxidative phosphorylation machinery. Therefore, their …

Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA
types of mitochondria. Although the number of mitochondrial RNA modifications is less than …

Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that
increase the diversity of its composition and activity. In mitochondria, specialized …