Plasma utilization has increased over the past two decades, and there is a growing concern
that many plasma transfusions are inappropriate. Plasma transfusion is not without risk, and …

T donors who are associated with TRALI events and how to reduce the risk of TRALI for
recipients of blood products. To address these issues, a Consensus Conference was …

The prevention and management of bleeding and thrombosis in patients with cirrhosis
poses several difficult clinical questions. These Clinical Practice Guidelines have been …

Objective To develop evidence-based clinical practice recommendations regarding
transfusion practices in non-bleeding, critically ill adults. Design A task force involving 13 …

Massive transfusion (MT) is a lifesaving treatment of hemorrhagic shock, but can be
associated with significant complications. The lethal triad of acidosis, hypothermia, and …

Three decades ago, transfusion-related acute lung injury (TRALI) was considered a rare
complication of transfusion medicine. Nowadays, the US Food and Drug Administration …

Adverse drug reactions (ADRs) result in major health problems in the United States in both
the inpatient and outpatient setting. ADRs are broadly categorized into predictable (type A …

BACKGROUND: Antibodies to human leukocyte antigens (HLA) in donated blood have
been implicated as a cause of transfusion‐related acute lung injury (TRALI). A potential …

Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory
overload (TACO) are the leading causes of transfusion-related morbidity and mortality …

Ever since platelet transfusions were shown to reduce mortality from haemorrhage in
patients with acute leukaemia in the 1950s, the use of this therapy has steadily grown to …