Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative
role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate …

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations
of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role …

Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

INTRODUCTION Neuronal communication at excitatory synapses in the brain involves
release of the neurotransmitter l-glutamate from the presynapse of one cell and its detection …

GRIA1 encodes the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate
(AMPA) receptors, which are ligand-gated ion channels that act as excitatory receptors for …

Loss-of-function technologies, such as morpholino-and RNAi-mediated gene knockdown,
and TALEN-and CRISPR/Cas9-mediated gene knockout, are widely used to investigate …

Ionotropic glutamate receptors (iGluRs) are a major class of ligand‐gated ion channels that
are widespread in the living kingdom. Their critical role in excitatory neurotransmission and …

Understanding rare genetic brain disorders with overlapping neurological and psychiatric
phenotypes is of increasing importance given the potential for developing disease models …

Using trio whole-exome sequencing, we have identified de novo heterozygous pathogenic
variants in GRIA4 in five unrelated individuals with intellectual disability and other …