The application of exosomes as a therapeutic reagent or drug delivery vehicle can be
expanded by developing a method to preserve exosomes. Although exosomes are …

The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded
delivery systems that maintain stability and potency for long times under ambient conditions …

Purpose Resistance to chemotherapeutic agents such as doxorubicin is a major reason for
cancer treatment failure. At present the treatment option for metastatic breast cancer is very …

Localized delivery of drugs is an emerging field both with regards to drug delivery during
disease as well as in tissue engineering. Despite significant achievements made in the last …

RNA interference (RNAi) has been harnessed to produce a new class of drugs for treatment
of various diseases. This review summarizes the most important parameters that govern the …

Introduction Long-term stability of therapeutic candidates is necessary toward their clinical
applications. For most nanoparticle systems formulated in aqueous solutions, lyophilization …

Sustained antiviral responses of chronic hepatitis C virus (HCV) infection have improved
recently by the use of direct-acting antiviral agents along with interferon (IFN)-α and ribavirin …

There is a compelling need for the development of suitable adjuvants for human use to
enhance the efficacy of the upcoming vaccines for the prevention of life threatening …

Nanoparticle based siRNA formulations often suffer from aggregation and loss of function
during storage. We in this study report a frozen targeted RGD-polyethylene glycol (PEG) …

Purpose Regulation of gene expression using small interfering RNA (siRNA) is a promising
strategy for treatments of numerous diseases. However, the progress towards broad …