Proliferative vitreoretinopathy: an update on the current and emerging treatment options

L Ferro Desideri, D Artemiev, S Zandi… - Graefe's Archive for …, 2024 - Springer
Proliferative vitreoretinopathy (PVR) remains the main cause of failure in retinal detachment
(RD) surgery and a demanding challenge for vitreoretinal surgeons. Despite the large …

[HTML][HTML] Intravitreal methotrexate

F Abdi, SS Mohammadi… - Journal of Ophthalmic & …, 2021 - ncbi.nlm.nih.gov
Intravitreal methotrexate (MTX) has been proven to be an effective treatment for various
intraocular diseases. In this article, a comprehensive review was performed on intravitreal …

Adjunctive serial post-operative intravitreal methotrexate injections in the management of advanced proliferative vitreoretinopathy

JA Roca, A Yon-Mendoza, N Huamán, L Wu - Graefe's Archive for Clinical …, 2021 - Springer
Purpose To assess the effects of weekly post-operative intravitreal methotrexate injections
on eyes with grade C proliferative vitreoretinopathy (PVR) that underwent surgical repair …

Anatomical and functional outcomes of vitrectomy with/without intravitreal methotrexate infusion for management of proliferative vitreoretinopathy secondary to …

S El Baha, M Leila, A Amr… - Journal of …, 2021 - Wiley Online Library
Purpose. To assess the anatomical and functional outcomes of intravitreal infusion of
methotrexate (MTX) during pars plana vitrectomy (PPV) for proliferative vitreoretinopathy …

Low-dose intravitreal methotrexate for proliferative vitreoretinopathy

A Ullah, CA Toth, HW Burnett, JW Butler… - … Surgery, Lasers and …, 2023 - journals.healio.com
Background and Objective: Proliferative vitreoretinopathy (PVR) has been mitigated by
intravitreal methotrexate (MTX) 400 μg/0.1 mL in several studies. Here, we evaluate the …

[HTML][HTML] Use of intravitreal methotrexate infusion in complicated retinal detachment for prevention of proliferative vitreoretinopathy in a pilot study

S Jahangir, T Jahangir, MH Ali, Q Lateef, U Hamza… - Cureus, 2021 - ncbi.nlm.nih.gov
Objective The objective of this pilot study was to evaluate the efficacy and safety of per-
operative intravitreal methotrexate (MTX) infusion during vitrectomy in patients of retinal …

[HTML][HTML] Inhibition of proliferative vitreoretinopathy by a newly developed methotrexate loaded drug carrier in vitro

SS Arrow, SC Felis, A Hillenmayer, LD Strehle… - Biomedicine & …, 2023 - Elsevier
Purpose Repeated intravitreal injections of methotrexate for proliferative vitreoretinopathy, a
rare ocular condition that can cause vision loss, have shown beneficial effects in recent …

Intravitreal methotrexate for the prevention and treatment of proliferative vitreoretinopathy in rhegmatogenous retinal detachment: a systematic review

M Balas, A Abdelaal, MM Popovic… - … Surgery, Lasers and …, 2022 - journals.healio.com
This systematic review evaluates the role of methotrexate (MTX) as an adjunctive intravitreal
agent for the prevention and treatment of proliferative vitreoretinopathy (PVR) in …

Combined 5-fluorouracil and low molecular weight heparin for the prevention of postoperative proliferative vitreoretinopathy in patients with retinal detachment: a meta …

C Chen, P Chen, X Liu, H Li - Frontiers in Medicine, 2021 - frontiersin.org
Background: Postoperative proliferative vitreoretinopathy (PVR) remains a dilemma for
retinal surgeons. We performed a literature search and meta-analyses to figure out whether …

Effects of repeated intra-silicone oil injections of methotrexate on proliferative vitreoretinopathy grade C: a multicenter randomized controlled trial

R Nourinia, S Safi, M Mohammadpour… - Scientific Reports, 2024 - nature.com
In this randomized controlled trial, we assessed the effects of three consecutive intra-silicone
oil (SO) injections of methotrexate (MTX) on the outcomes of surgery for proliferative …