Atherothrombosis is a leading cause of cardiovascular mortality and morbidity worldwide.
The underlying mechanisms of atherothrombosis comprise plaque disruption and …

Summary von Willebrand factor (VWF) is a key player in hemostasis, acting as a carrier for
factor VIII and capturing platelets at sites of vascular damage. To capture platelets, it must …

Background Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased
risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased …

Thrombus formation on disrupted atherosclerotic plaques is generally considered as being a
trigger for atherothrombosis, namely the onset of cardiovascular events. Since thrombus …

VWF biosynthesis, maturation, and secretion is a complex process, which mandates tight
regulation. Significant progress has been made in our understandings of VWF expression …

A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases.
ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are …

Background von Willebrand factor (VWF) and its cleaving protease, ADAMTS-13, form a
pivotal axis that regulates hemostasis. However, the role of the VWF-ADAMTS-13 axis in the …

Dysfunction of endothelial cells of the artery wall is an early event in cardiovascular disease
and atherosclerosis. The cause (s) of this dysfunction are unresolved, but accumulating …

Various symptoms have been reported to persist beyond the acute phase of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which is referred to as long …

Background Deep vein thrombosis (DVT) is a common multi-factorial disease with a partially
understood aetiology. Although the roles of high factor (F) VIII and von Willebrand factor …