Rational materials design based on prior knowledge is attractive because it promises to
avoid time-consuming synthesis and testing of numerous materials candidates. However …

Prins cyclization has emerged as one of the most valuable methods for the construction of
heterocycles. It proceeds through intramolecular addition of a π‐nucleophile to an …

All stereoisomers of the natural product centrolobine are selectively synthesized, by starting
from a common precursor. Key steps are an enantioselective allylation with enantiomerically …

Cyanobacterial cyclopeptides: A series of analogues of the cyanobacterial cyclopeptide
brunsvicamide A was prepared by effective solid‐support‐based total synthesis. Variations …

Hetereocycles are structures present in a wide variety of biologically active natural products.
Within the protocols used to prepare these substrates, the silyl-Prins cyclization has shown …

Heterocyclic compounds are of high importance in constructing active drug intermediates
library. The emergence of solid-phase and combinatorial chemistry has led to renewed …

A versatile combinatorial approach was developed for the rapid synthesis of 2, 5-dihydro-1
H-pyrroles, 1, 3-dioxo-2, 3, 5, 7 a-tetrahydro-1 H-pyrrolo [1, 2-c] imidazoles, and 1, 4-dioxo-1 …

A transition metal-free domino process has been developed, for the first time, to synthesize
(E)-stilbenes, biaryl methanes and biaryl ethers from substituted α, β-unsaturated ketones …

For many years proteases have been viewed as important targets for the pharmaceutical
industry. Potent inhibitors for the four classes of proteases (cysteine-, aspartyl-, serineand …

Cyclopentanes and cyclopentenes are present in many natural products and
pharmaceuticals. Despite their presence in many natural products and pharmaceuticals …