Antibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs)
due to the severity of complications accompanying neonatal sepsis. However, antimicrobial …

Background Determining which babies should receive antibiotics for potential early onset
sepsis (EOS) is challenging. We performed a meta-analysis quantifying how many EOS …

Immune function and sensitivity to pain are closely related, but the association between
early life inflammation and sensory nervous system development is poorly understood …

The expert guidelines highlighted in this review provide an evidence-based framework for
approaching at-risk infants and allow for a more limited and standardised approach to …

Objective Assess the impact of introducing a consensus guideline incorporating an adapted
Sepsis Risk Calculator (SRC) algorithm, in the management of early onset neonatal sepsis …

Background Infants are frequently exposed to antibiotics (AB) in the first week of life for
suspected bacterial infections. Little is known about the effect of AB on the developing …

Objectives To provide a comprehensive assessment of case stratification by the Neonatal
Early-Onset Sepsis (EOS) Calculator, a novel tool for reducing unnecessary antibiotic …

Objective To compare the management recommendations of the Kaiser Permanente
neonatal early-onset sepsis risk calculator (SRC) with National Institute for Health and Care …

Background The early-onset sepsis calculator (EOSC) reduces unnecessary antibiotic
treatment in newborns. However, its performance in identifying cases with early-onset …

OBJECTIVES We aimed to study whether national and local antibiotic stewardship projects
have reduced the antibiotic use in newborns and to monitor potential changes in adverse …