The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …

Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A
mechanism linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich …

To directly test the contribution of Scgb1a1+ Clara cells to postnatal growth, homeostasis,
and repair of lung epithelium, we generated a Scgb1a1-CreER TM" knockin" mouse for …

Developmental lung biology is a field that has the potential for significant human impact:
lung disease at the extremes of age continues to cause major morbidity and mortality …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Goblet cell hyperplasia and mucous hypersecretion contribute to the pathogenesis of
chronic pulmonary diseases including cystic fibrosis, asthma, and chronic obstructive …

The identity of the endogenous epithelial cells in the adult lung that are responsible for
normal turnover and repair after injury is still controversial. In part, this is due to a paucity of …

Lung diseases remain a significant and devastating cause of morbidity and mortality
worldwide. In contrast to many other major diseases, lung diseases notably chronic …

Lung development is the result of complex interactions between four tissues: epithelium,
mesenchyme, mesothelium and endothelium. We marked the lineages experiencing Notch1 …