Plant kunitz inhibitors and their interaction with proteases: Current and potential pharmacological targets

CR Bonturi, AB Silva Teixeira, VM Rocha… - International Journal of …, 2022 - mdpi.com
The action of proteases can be controlled by several mechanisms, including regulation
through gene expression; post-translational modifications, such as glycosylation; zymogen …

Cutaneous Melanoma: An Overview of Physiological and Therapeutic Aspects and Biotechnological Use of Serine Protease Inhibitors

APDA Boleti, AC Jacobowski, T Monteiro-Alfredo… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Metastatic melanoma stands out as the most lethal form of skin cancer because
of its high propensity to spread and its remarkable resistance to treatment methods …

Peptides Derived from a Plant Protease Inhibitor of the Coagulation Contact System Decrease Arterial Thrombus Formation in a Murine Model, without Impairing …

DA De Souza, BR Salu, RS Nogueira… - Journal of Clinical …, 2023 - mdpi.com
Several plant protein inhibitors with anticoagulant properties have been studied and
characterized, including the Delonix regia trypsin inhibitor (DrTI). This protein inhibits serine …

A fluorescent quantum dot conjugate to probe the interaction of Enterolobium contortisiliquum trypsin inhibitor with cancer cells

NRM Santos, WF de Oliveira, MP Cabrera… - International Journal of …, 2023 - Elsevier
Serine proteases play crucial biological roles and have their activity controlled by inhibitors,
such as the EcTI, a serine protease inhibitor purified from Enterolobium contortisiliquum …

Differences in the inhibitory specificity distinguish the efficacy of plant protease inhibitors on mouse fibrosarcoma

S Yoo Im, C Ramalho Bonturi, A Miti Nakahata… - Plants, 2021 - mdpi.com
Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple
protease-mediated processes. Thus, effort has been invested in the development of …

Quantum dot-based conjugates: Luminous nanotools for cancer research

RBL Henrique, JVA Lima, ALF Santos… - Biochemical and …, 2024 - Elsevier
Nanotechnology has opened a new era in life science research, offering innovative
nanotools to understand complex biological processes, such as those associated with …

A review on protease inhibitors of herbal origin to combat malignancy

S Bhattacharya - Journal of Environmental Pathology …, 2024 - dl.begellhouse.com
Protease is the enzyme accountable for the breakdown of proteins ie, proteolysis. Proteases
are reportedly involved in the events of growth, development, progression and metastasis of …

Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S

RC Sallai, BR Salu, RA Silva-Lucca, FL Alves… - Plants, 2020 - mdpi.com
Protease inhibitors are involved in the regulation of endogenous cysteine proteases during
seed development and play a defensive role because of their ability to inhibit exogenous …

The First Anti-Snakebite and Hepatoprotective Characterization of a Trypsin Kunitz-like Inhibitor (EcTI) from the Plant Enterolobium contortisiliquum; A Case of Two …

CRC Costa, MN Belchor, A Roggero, LL Moraes… - Pharmaceuticals, 2023 - mdpi.com
Snake venom serine protease (SVSP) interferes with the regulation and control of important
biological reactions in homeostasis and can be classified as an activator of the fibrinolytic …

Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI

M Li, J Srp, M Mareš, A Wlodawer… - … Section D: Structural …, 2021 - journals.iucr.org
Structures of BbKI, a recombinant Kunitz-type serine protease inhibitor from Bauhinia
bauhinioides, complexed with human kallikrein 4 (KLK4) were determined at medium-to …