Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Glutamate, a nonessential amino acid, is a major bioenergetic substrate for proliferating
normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively …

Glutamate is the major excitatory neurotransmitter in the central nervous system and is
intricately linked to learning and memory. Its activity depends on the expression of AMPA …

Glutamate is the major excitatory neurotransmitter of the Central Nervous System (CNS),
and it is crucially needed for numerous key neuronal functions. Yet, excess glutamate …

Glutamate is the major excitatory neurotransmitter in the nervous system, where it induces
multiple beneficial and essential effects. Yet, excess glutamate, evident in a kaleidoscope of …

Glutamate is the most important excitatory neurotransmitter of the nervous system, critically
needed for the brain's development and function. Glutamate has also a signaling role in …

Ligand-gated ion channels are an ionotropic receptor subtype characterized by the binding
of an extracellular ligand, followed by the transient passage of ions through a …

Glutamate is one of the most abundant amino acids in the blood. Besides its role as a
neurotransmitter in the brain, it is a key substrate in several metabolic pathways and a …