Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …

Background Preterm birth (PTB), birth at< 37 weeks of gestation, is a significant global public
health problem. World-wide, about 15 million babies are born preterm each year resulting in …

Preterm birth (PTB) is the leading cause of newborn deaths around the world. Spontaneous
preterm birth (sPTB) accounts for two-thirds of all PTBs; however, there remains an unmet …

Matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) gene
polymorphisms have been extensively evaluated as predisposing factors to human …

Background: Preterm birth remains a major cause of neonatal morbidity and mortality.
Several potential pathways and pathophysiologic processes can lead to preterm birth …

Spontaneous preterm birth is a major public health problem, with a clear genetic component.
Genetic association studies have evolved substantially in recent years, moving away from …

Objective. The aim of this study was to investigate the association of functional MMP-1‐1607
1G/2G and MMP-9‐1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; …

Regulatory T lymphocytes play a critical role in immune regulation and are involved in the
aberrant cell elimination by facilitating tumor necrosis factor connection to the TNFR2 …

Despite decades of investigations and accumulated scientific knowledge, preterm birth
(PTB) remains a significant burden worldwide. Several mechanisms have been proposed to …

Background Despite various genomic approaches used in prior studies investigating the
association of maternal genetic variability with spontaneous preterm birth (sPTB), results …