Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and
structure data have radically transformed computational protein design. New methods …

Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …

Phage display was first described by George P. Smith when it was shown that virus particles
were capable of presenting foreign proteins on their surface. The technology has paved the …

Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

Following viral infection, viral antigens bind specifically to receptors on the surface of
lymphocytes thereby activating adaptive immunity in the host. An epitope, the smallest …

Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most
important classes of biotherapeutics in recent decades. The success of mAb is due to their …

Peptide quantitative structure-activity relationship (pQSAR) is a specific extension of
traditional QSARs from small-molecule drugs to bioactive peptides. Since peptides are …

Microfluidics are systems that set forth valuable means to efficiently control fluid movement
and dynamics in specially fabricated micro-channel systems. The advancement of the …

Phage display enables to screen probes such as peptide, antibody and nanobody with high
specificity and affinity to the target, providing excellent probes for various analytical or …

Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals
despite significant challenges and risks to their discovery and development. This review …