Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

The physical interaction of proteins which lead to compiling them into large densely
connected networks is a noticeable subject to investigation. Protein interaction networks are …

Abstract The Database of Interacting Proteins (http://dip. doe‐mbi. ucla. edu) aims to
integrate the diverse body of experimental evidence on protein–protein interactions into a …

Protein-protein interactions are of great significance for human to understand the functional
mechanisms of proteins. With the rapid development of high-throughput genomic …

Proteins do not function in isolation; it is their interactions with one another and also with
other molecules (eg DNA, RNA) that mediate metabolic and signaling pathways, cellular …

Motivation: Despite advances in high-throughput methods for discovering protein–protein
interactions, the interaction networks of even well-studied model organisms are sketchy at …

Motivation: High-throughput experiments are being performed at an ever-increasing rate to
systematically elucidate protein–protein interaction (PPI) networks for model organisms …

Motivation: Protein interactions are of biological interest because they orchestrate a number
of cellular processes such as metabolic pathways and immunological recognition. Domains …

Protein–protein interactions play a key role in many biological systems. High‐throughput
methods can directly detect the set of interacting proteins in yeast, but the results are often …

Assigning functions to novel proteins is one of the most important problems in the post-
genomic era. We develop a novel approach that applies the theory of Markov random fields …