This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Carbohydrate antigens are immune targets associated with a variety of pathogens and
tumor cells. Unfortunately, most carbohydrates are intrinsically T cell-independent antigens …

Tumor cells are characterized by the expression of tumor-specific carbohydrate structures
that differ from their normal counterparts. Carbohydrates on tumor cells have phenotypical …

Introduction Because of its restricted distribution in normal tissues and its high expression on
tumors of neuroectodermal origin, GD2 ganglioside is an excellent target for active specific …

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from
foreign pathogen products to abnormal cellular components such as in cancer. However, an …

The tumor-associated carbohydrate Thomsen-Friedenreich antigen (TF-Ag; Galß1-
3GalNAcα-O-Ser/Thr) is overexpressed on the cell surface of several types of tumor cells …

Peptide mimetics may substitute for carbohydrate antigens in vaccine design applications. At
present, the structural and immunological aspects of antigenic mimicry, which translate into …

Molecular mimicry is fundamental to biology and transcends to many disciplines ranging
from immune pathology to drug design. Structural characterization of molecular partners has …

Protein conjugates of oligosaccharides or peptides that mimic complex bacterial
polysaccharide antigens represent alternatives to the classical polysaccharide-based …

Immunization with peptide mimetics of carbohydrate antigens can induce functional
carbohydrate-reactive antibodies. Here, we examine the immune characteristics of …