Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors

R Bai, Z Lv, D Xu, J Cui - Biomarker research, 2020 - Springer
Although the clinical development of immune checkpoint inhibitors (ICIs) therapy has
ushered in a new era of anti-tumor therapy, with sustained responses and significant …

[HTML][HTML] DNA methylation in lung cancer patients: Opening a" window of life" under precision medicine

R Liang, X Li, W Li, X Zhu, C Li - Biomedicine & Pharmacotherapy, 2021 - Elsevier
DNA methylation is a work of adding a methyl group to the 5th carbon atom of cytosine in
DNA sequence under the catalysis of DNA methyltransferase (DNMT) to produce 5-methyl …

[HTML][HTML] Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers

C Hu, L Zhao, W Liu, S Fan, J Liu, Y Liu… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Diagnosing and treating patients with multiple primary lung cancers (MPLCs)
bring challenges to the clinic, and the preliminary evidence has revealed unsatisfying …

New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities

M Dai, M Liu, H Yang, C Küçük, H You - Experimental Hematology & …, 2022 - Springer
Programmed cell death protein 1 (PD-1) is a type of immune-inhibitory checkpoint protein,
which delivers inhibitory signals to cytotoxic T cells by binding to the programmed death …

[HTML][HTML] Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy

S Guo, X Zhu, Z Huang, C Wei, J Yu, L Zhang… - Biomedicine & …, 2023 - Elsevier
Genetic instability can be caused by external factors and may also be associated with
intracellular damage. At the same time, there is a large body of research investigating the …

Relationship among DDR gene mutations, TMB and PD-L1 in solid tumour genomes identified using clinically actionable biomarker assays

D Wang, B Elenbaas, K Murugesan, K Shah… - NPJ Precision …, 2023 - nature.com
The DNA damage response (DDR) pathway regulates DNA repair and cell survival, and
inactivating mutations in DDR genes can increase tumour mutational burden (TMB), a …

Liquid biopsy for early diagnosis of non-small cell lung carcinoma: recent research and detection technologies

L Chang, J Li, R Zhang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Liquid biopsy, an innovative method for early diagnosis of cancer, has changed the
traditional method of diagnosing lung cancer and is considered a feasible auxiliary …

Potential biomarkers for immunotherapy in non-small-cell lung cancer

X Wang, Z Qiao, B Aramini, D Lin, X Li, J Fan - Cancer and Metastasis …, 2023 - Springer
For individuals with advanced or metastatic non-small cell lung cancer (NSCLC), the primary
treatment is platinum-based doublet chemotherapy. Immune checkpoint inhibitors (ICIs) …

EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells

H Gong, Y Li, Y Yuan, W Li, H Zhang, Z Zhang, R Shi… - BMC cancer, 2020 - Springer
Background Lung cancer is the leading cause of cancer-related deaths worldwide. Non-
small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti …

A methylation-based reclassification of bladder cancer based on immune cell genes

Q Luo, TA Vögeli - Cancers, 2020 - mdpi.com
Simple Summary Bladder cancer (BC) development is highly related to immune cell
infiltration. In this study, we aimed to construct a new classification of bladder cancer …