CRISPR gene therapy: applications, limitations, and implications for the future

F Uddin, CM Rudin, T Sen - Frontiers in oncology, 2020 - frontiersin.org
A series of recent discoveries harnessing the adaptive immune system of prokaryotes to
perform targeted genome editing is having a transformative influence across the biological …

Gene editing and CRISPR in the clinic: current and future perspectives

MP Hirakawa, R Krishnakumar, JA Timlin… - Bioscience …, 2020 - portlandpress.com
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …

[HTML][HTML] The genome editing revolution

AM Khalil - Journal of genetic engineering and biotechnology, 2020 - Elsevier
Background Development of efficient strategies has always been one of the great
perspectives for biotechnologists. During the last decade, genome editing of different …

[HTML][HTML] TALENs—an indispensable tool in the era of CRISPR: a mini review

A Bhardwaj, V Nain - Journal of Genetic Engineering and Biotechnology, 2021 - Elsevier
Background Genome of an organism has always fascinated life scientists. With the discovery
of restriction endonucleases, scientists were able to make targeted manipulations …

CRISPR/Cas system and factors affecting its precision and efficiency

N Javaid, S Choi - Frontiers in cell and developmental biology, 2021 - frontiersin.org
The diverse applications of genetically modified cells and organisms require more precise
and efficient genome-editing tool such as clustered regularly interspaced short palindromic …

[PDF][PDF] Patient data ownership: who owns your health?

K Liddell, DA Simon, A Lucassen - Journal of Law and the …, 2021 - academic.oup.com
This article answers two questions from the perspective of United Kingdom law and policy:(i)
is health information property? and (ii) should it be? We argue that special features of health …

Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies

H Dabiri, P Safarzadeh Kozani, M Habibi Anbouhi… - Biomarker …, 2023 - Springer
Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically
engineered immune cells that can detect target antigens on the surface of target cells and …

Exploring parkinson-associated kinases for CRISPR/cas9-based gene editing: beyond alpha-synuclein

HM Mansour, AS El-Khatib - Ageing Research Reviews, 2023 - Elsevier
Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substania nigra (SN) and is associated with progressive …

Genetic disease and therapy

TL Roth, A Marson - Annual Review of Pathology: Mechanisms …, 2021 - annualreviews.org
Genetic diseases cause numerous complex and intractable pathologies. DNA sequences
encoding each human's complexity and many disease risks are contained in the …

CRISPR-Cas9 system: a genome-editing tool with endless possibilities

S Tyagi, R Kumar, A Das, SY Won, P Shukla - Journal of Biotechnology, 2020 - Elsevier
The discovery of CRISPR: Cas9 and its application as a powerful gene-editing tool has
transformed the world of basic and applied science, especially the molecular biology dome …