5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and
chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX) …

Simple Summary In the era of targeted therapies, achieving a maximal safe resection still
remains a critical prognosis factor in diffuse low-grade gliomas and represents the goal to …

Over the past decade, the utilization of advanced fluorescence microscopy technologies has
presented numerous opportunities to study or re-investigate autofluorescent molecules and …

Significance: 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence
is currently used for image-guided glioma resection. Typically, this widefield imaging method …

Purpose Modern techniques for improved tumor visualization have the aim to maximize the
extent of resection during brain tumor surgery and thus improve patient prognosis. Optical …

Fluorescence-guided surgery has emerged as a vital tool for tumour resection procedures.
As well as intraoperative tumour visualisation, 5-ALA-induced PpIX provides an avenue for …

The review begins with an overview of the fundamental principles/physics underlying light,
fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5 …

Introduction The clinical impact of 5-aminolevulinic acid (5-ALA) fluorescence during
resection of brain metastases is not yet clear.. Recent data demonstrated significantly lower …

Precise intraoperative brain tumor visualization supports surgeons in achieving maximal
safe resection. In this sense, improved prognosis in patients with high-grade gliomas …

Detection of oral mucosal lesions has been performed by an in-house developed
fluorescence-based portable device in the present study. A laser diode of 405 nm …