Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

Abstract The NCI's Cloud Resources (CR) are the analytical components of the Cancer
Research Data Commons (CRDC) ecosystem. This review describes how the three CRs …

With the increasing use of comprehensive germline genetic testing of children and
adolescents with cancer, it has become evident that pathogenic variants (PVs) in adult-onset …

Background High-risk neuroblastoma is a complex genetic disease that is lethal in more
than 50% of patients despite intense multimodal therapy. Through genome-wide association …

Background Sarcomas are a rare and diverse group of cancers occurring mainly in young
individuals for which an underlying germline genetic cause remains unclear in most cases …

Importance Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
Of the patients who develop MCC annually, only 4% are younger than 50 years. Objective …

Simple Summary Ewing sarcoma is a malignant pediatric bone cancer currently lacking
targeted therapy. In the US there are~ 200 patients diagnosed each year and relapse is …

Genetic predisposition is an important risk factor for cancer in children and adolescents but
detailed associations of individual genetic mutations to childhood cancer are still under …

Pediatric cancer outcomes have significantly improved, and yet this success is not spread
equally across cancer types or patients. Disparities data in pediatric oncology highlight …

Utilization of tumor‐only sequencing has expanded in pediatric cancer patients, which can
lead to identification of pathogenic variants in genes that may be germline and/or have …