Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment

A Ajoolabady, M Chiong, S Lavandero… - Trends in molecular …, 2022 - cell.com
With the growing prevalence of cardiovascular disease (CVD), there is an urgent need to
explore non-conventional therapeutic measures to alleviate the burden of CVD on global …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies

JS Bhatti, GK Bhatti, PH Reddy - … et Biophysica Acta (BBA)-Molecular Basis …, 2017 - Elsevier
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

Cardiomyocyte death: mechanisms and translational implications

M Chiong, ZV Wang, Z Pedrozo, DJ Cao… - Cell death & …, 2011 - nature.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide.
Although treatments have improved, development of novel therapies for patients with CVD …

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease

FG Tahrir, D Langford, S Amini… - Journal of cellular …, 2019 - Wiley Online Library
Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

Assessing cardiac metabolism: a scientific statement from the American Heart Association

H Taegtmeyer, ME Young, GD Lopaschuk… - Circulation …, 2016 - Am Heart Assoc
In a complex system of interrelated reactions, the heart converts chemical energy to
mechanical energy. Energy transfer is achieved through coordinated activation of enzymes …

[HTML][HTML] Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant …

PH Reddy, R Tripathi, Q Troung, K Tirumala… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's
disease (AD) progression. Loss of synapses and synaptic damage are the best correlates of …

Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway

C Pennanen, V Parra, C Lopez-Crisosto… - Journal of cell …, 2014 - journals.biologists.com
Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism.
Mitochondria are crucial organelles for the production of ATP, and their morphology and …

Role of cell death in the progression of heart failure

GW Moe, J Marín-García - Heart failure reviews, 2016 - Springer
All multicellular organisms develop during evolution the highly regulated and interconnected
pathways of cell death. This complex network contributes to the pathogenesis of various …

Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation

M Chiong, B Cartes-Saavedra… - Frontiers in cell and …, 2014 - frontiersin.org
Differentiation and dedifferentiation of vascular smooth muscle cells (VSMCs) are essential
processes of vascular development. VSMC have biosynthetic, proliferative, and contractile …

Cardiomyocyte mitochondrial dynamics in health and disease and the role of exercise training: A brief review

B Ebadi, A Damirchi, KA Alamdari… - Research in …, 2018 - journals.lww.com
Mitochondria as dynamic organelle constantly undergo fusion and fission reactions, leading
to continuous reconstruction of the mitochondrial network for elongated or fragmentation …