There is a growing interest in using natural medicines to treat stroke as the leading cause of
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …

The past two decades have witnessed remarkable advances in oxidative stress research,
particularly in the context of ischemic brain injury. Oxidative stress in ischemic tissues …

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …

Whereas the contribution of tumor microenvironment to the profound immune suppression of
glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 …

In response to DNA double-strand breaks or oxidative stress, ATM-dependent DNA damage
response (DDR) is activated to maintain genome integrity. However, it remains elusive …

Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of
numerous human diseases. Oxidative damage to telomeric DNA has been proposed to …

Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its
effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide …

Telomeres are hypersensitive to the formation of the common oxidative lesion 8-oxoguanine
(8oxoG), which impacts telomere stability and function. OGG1 and MUTYH glycosylases …

To develop an in vivo tool to probe brain genotoxic stress, we designed a viral proxy as a
single-cell genetic sensor termed PRISM that harnesses the instability of recombinant adeno …

Abstract cAMP response element-binding (CREB) protein is a cellular transcription factor
that mediates responses to different physiological and pathological signals. Using a model …