Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
A heart for diversity: simulating variability in cardiac arrhythmia research
In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …
These include variability in conditions and environment, and genotypic and molecular …
Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are
sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the …
sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the …
Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
S Dutta, KC Chang, KA Beattie, J Sheng… - Frontiers in …, 2017 - frontiersin.org
Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many
drugs from the market and is therefore of major concern to global regulatory agencies and …
drugs from the market and is therefore of major concern to global regulatory agencies and …
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
This white paper presents principles for validating proarrhythmia risk prediction models for
regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research …
regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research …
Unlocking data sets by calibrating populations of models to data density: A study in atrial electrophysiology
The understanding of complex physical or biological systems nearly always requires a
characterization of the variability that underpins these processes. In addition, the data used …
characterization of the variability that underpins these processes. In addition, the data used …
Validation and trustworthiness of multiscale models of cardiac electrophysiology
P Pathmanathan, RA Gray - Frontiers in Physiology, 2018 - frontiersin.org
Computational models of cardiac electrophysiology have a long history in basic science
applications and device design and evaluation, but have significant potential for clinical …
applications and device design and evaluation, but have significant potential for clinical …
Simulation of the effects of extracellular calcium changes leads to a novel computational model of human ventricular action potential with a revised calcium handling
The importance of electrolyte concentrations for cardiac function is well established.
Electrolyte variations can lead to arrhythmias onset, due to their important role in the action …
Electrolyte variations can lead to arrhythmias onset, due to their important role in the action …
Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems
While cardiomyocytes differentiated from human induced pluripotent stems cells (hiPSCs)
hold great promise for drug screening, the electrophysiological properties of these cells can …
hold great promise for drug screening, the electrophysiological properties of these cells can …
A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome
C Jiang, E Richardson, J Farr, AP Hill, R Ullah… - The American Journal of …, 2022 - cell.com
Modern sequencing technologies have revolutionized our detection of gene variants.
However, in most genes, including KCNH2, the majority of missense variants are currently …
However, in most genes, including KCNH2, the majority of missense variants are currently …