Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches
Spray drying is increasingly becoming recognized as an efficient drying and formulation
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
technique for pharmaceutical and biopharmaceutical processing. It offers significant …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Co-amorphous drug formulations in numbers: Recent advances in co-amorphous drug formulations with focus on co-formability, molar ratio, preparation methods …
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …
or more (initially crystalline) low molecular weight components that form a homogeneous …
Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations
Spray drying is an efficient technology for solid dispersion manufacturing since it allows
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …
Three-dimensional printed PCL-based implantable prototypes of medical devices for controlled drug delivery
J Holländer, N Genina, H Jukarainen… - Journal of …, 2016 - Elsevier
The goal of the present study was to fabricate drug-containing T-shaped prototypes of
intrauterine system (IUS) with the drug incorporated within the entire backbone of the …
intrauterine system (IUS) with the drug incorporated within the entire backbone of the …
Hansen solubility parameter as a tool to predict cocrystal formation
MA Mohammad, A Alhalaweh, SP Velaga - International journal of …, 2011 - Elsevier
The objective of this study was to investigate whether the miscibility of a drug and coformer,
as predicted by Hansen solubility parameters (HSPs), can indicate cocrystal formation and …
as predicted by Hansen solubility parameters (HSPs), can indicate cocrystal formation and …
Theoretical and practical approaches for prediction of drug–polymer miscibility and solubility
PJ Marsac, SL Shamblin, LS Taylor - Pharmaceutical research, 2006 - Springer
Purpose Crystallization of drugs formulated in the amorphous form may lead to reduced
apparent solubility, decreased rate of dissolution and bioavailability and compromise the …
apparent solubility, decreased rate of dissolution and bioavailability and compromise the …
Amino acids as co-amorphous stabilizers for poorly water soluble drugs–Part 1: Preparation, stability and dissolution enhancement
K Löbmann, H Grohganz, R Laitinen, C Strachan… - European journal of …, 2013 - Elsevier
Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most
pressing problems in pharmaceutical research and development because up to 90% of new …
pressing problems in pharmaceutical research and development because up to 90% of new …
Estimation of drug–polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters
PJ Marsac, T Li, LS Taylor - Pharmaceutical research, 2009 - Springer
Purpose The amorphous form of a drug may provide enhanced solubility, dissolution rate,
and bioavailability but will also potentially crystallize over time. Miscible polymeric additives …
and bioavailability but will also potentially crystallize over time. Miscible polymeric additives …