Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …

INTRODUCTION Voltage-gated sodium (Nav) channels open and close ion-selective pores
in response to changes in membrane potential, and this gating underlies the generation of …

The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is
an important drug target to treat epilepsy, pain and several other diseases related to …

Mutations in the KV7. 2 gene encoding for voltage-dependent K+ channel subunits cause
neonatal epilepsies with wide phenotypic heterogeneity. Two mutations affecting the same …

Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for
therapy and mainly involves a classic gating mechanism that augments the native voltage …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDS) produce deleterious side
effects and fail to provide sustained relief in patients with chronic inflammatory pain …

The voltage-gated proton channel Hv1 plays important roles in proton extrusion, pH
homeostasis, and production of reactive oxygen species in a variety of cell types. Excessive …

Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and
controlled by a complement of ion channels it expresses, in order to understand and treat …