With recent advances in cancer therapeutics, there is a great need for improved imaging
methods for characterizing cancer onset and progression in a quantitative and actionable …

This paper presents a microscopic imaging technique that uses variable-angle illumination
to recover the complex polarimetric properties of a specimen at high resolution and over a …

Structural and thermodynamic transitions of artificially designed α-helical nanofibers were
investigated using eight peptide variants, including four peptides with amide-modified …

When the skin is exposed to ultraviolet radiation (UV), it leads to the degradation of the
extracellular matrix (ECM) and results in inflammation. Subsequently, melanocytes are …

Current tools lack the temporal or spatial resolution necessary to image many important
aspects of the architecture and dynamics of the optic nerve head (ONH). We evaluated the …

Collagen architecture determines the biomechanical environment in the eye, and thus
characterizing collagen fiber organization and biomechanics is essential to fully understand …

Stretch-induced collagen uncrimping underlies the nonlinear mechanical behavior of the
sclera according to what is often called the process of recruitment. We recently reported …

Sclera collagen fiber microstructure and mechanical behavior are central to eye physiology
and pathology. They are also complex, and are therefore often studied using modeling. Most …

Anisotropy is an important cue for neural organization during morphogenesis and healing,
contributing to the mechanical and functional properties of neural tissues. The ability to …

Significance The polarimetric properties of biological tissues are often difficult to ascertain
independent of their complex structural and organizational features. Conventional …