Towards complete and error-free genome assemblies of all vertebrate species

A Rhie, SA McCarthy, O Fedrigo, J Damas, G Formenti… - Nature, 2021 - nature.com
High-quality and complete reference genome assemblies are fundamental for the
application of genomics to biology, disease, and biodiversity conservation. However, such …

Evolutionary conservation in noncoding genomic regions

NA Leypold, MR Speicher - Trends in Genetics, 2021 - cell.com
Humans may share more genomic commonalities with other species than previously
thought. According to current estimates,~ 5% of the human genome is functionally …

Integrating gene annotation with orthology inference at scale

BM Kirilenko, C Munegowda, E Osipova, D Jebb… - Science, 2023 - science.org
Annotating coding genes and inferring orthologs are two classical challenges in genomics
and evolutionary biology that have traditionally been approached separately, limiting …

Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding

M Blumer, T Brown, MB Freitas, AL Destro… - Science …, 2022 - science.org
Vampire bats are the only mammals that feed exclusively on blood. To uncover genomic
changes associated with this dietary adaptation, we generated a haplotype-resolved …

Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample

M Sandoval-Velasco, O Dudchenko, JA Rodríguez… - Cell, 2024 - cell.com
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides
and aligning to genome assemblies from related, modern species. Here, we report that skin …

Convergent and lineage-specific genomic differences in limb regulatory elements in limbless reptile lineages

JG Roscito, K Sameith, BM Kirilenko, N Hecker… - Cell reports, 2022 - cell.com
Loss of limbs evolved many times in squamate reptiles. Here we investigated the genomic
basis of convergent limb loss in reptiles. We sequenced the genomes of a closely related …

The evolution history of an allotetraploid mangrove tree analysed with a new tool Allo4D

Y Wang, Y Li, W Wu, S Shao, Q Fang… - Plant Biotechnology …, 2024 - Wiley Online Library
Mangrove species are broadly classified as true mangroves and mangrove associates. The
latter are amphibious plants that can survive in the intertidal zone and reproduce naturally in …

Distinct Genes with Similar Functions Underlie Convergent Evolution in Myotis Bat Ecomorphs

AE Morales, FT Burbrink, M Segall… - Molecular Biology …, 2024 - academic.oup.com
Convergence offers an opportunity to explore to what extent evolution can be predictable
when genomic composition and environmental triggers are similar. Here, we present an …

A genome alignment of 120 mammals highlights ultraconserved element variability and placenta-associated enhancers

N Hecker, M Hiller - Gigascience, 2020 - academic.oup.com
Background Multiple alignments of mammalian genomes have been the basis of many
comparative genomic studies aiming at annotating genes, detecting regions under …

Prevalent Introgression Underlies Convergent Evolution in the Diversification of Pungitius Sticklebacks

Y Wang, Y Wang, X Cheng, Y Ding… - Molecular Biology …, 2023 - academic.oup.com
New mutations and standing genetic variations contribute significantly to repeated
phenotypic evolution in sticklebacks. However, less is known about the role of introgression …