Sequence alignment is an active research area in the field of bioinformatics. It is also a
crucial task as it guides many other tasks like phylogenetic analysis, function, and/or …

The D2 dopamine receptor (DRD2) has been one of the most extensively investigated gene
in neuropsychiatric disorders. After the first association of the TaqI A DRD2 minor (A1) allele …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …

In complex disease studies, it is crucial to perform multipoint linkage analysis with many
markers and to use robust nonparametric methods that take account of all pedigree …

Abstract Non–insulin–dependent (type 2) diabetes mellitus (NIDDM) is a common disorder
of middle–aged individuals characterized by high blood glucose levels which, if untreated …

Objective To determine if polymorphisms of the macrophage migration inhibitory factor (MIF)
gene are associated with juvenile idiopathic arthritis (JIA). Methods Denaturing high …

We have performed genetic linkage analysis in 13 large multiply affected families, to test the
hypothesis that there is extensive heterogeneity of linkage for genetic subtypes of …

A genomewide screen for asthma-and atopy-susceptibility loci was conducted, using 563
markers, in 693 Hutterites who are members of a single 15-generation pedigree, nearly …

Founder populations offer many advantages for mapping genetic traits, particularly complex
traits that are likely to be genetically heterogeneous. To identify genes that influence asthma …

In this short report, we address some practical problems in performing likelihood-based
allelic association analysis of case-control data. Model-free statistics are proposed and their …