Vascular diseases of the elderly are a topic of enormous interest in clinical practice, as they
have great epidemiological significance and lead to ever-increasing healthcare …

Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

Nitric oxide (NO)(co) regulates many physiological processes in the body. Its short-lived free
radicals force synthesis in situ and on-demand, without storage possibility. Local oxygen …

Cardiovascular diseases are the number one cause of death globally. The most important
determinant of cardiovascular health is a person's age. Aging results in structural changes …

Among the numerous identified cytochrome b5 reductase 3 (CYB5R3) variants, T117S
(rs1800457) stands out as a high-frequency variant (0.23 minor allele frequency) …

Inflammation causes bronchopulmonary dysplasia (BPD), a common lung disease of
preterm infants. One reason this disease lacks specific therapies is the paucity of information …

Ischemic cardiovascular disease and stroke remain the leading cause of global morbidity
and mortality. While aging, protective mechanisms in the body gradually deteriorate …

Introduction: Vascular aging is marked by increased mitochondrial reactive oxygen species
(ROS) production, which leads to decreased nitric oxide (NO)-mediated vasodilation. Loss of …

Doxorubicin (DOX) is restricted due to its severe cardiotoxicity. There is still a lack of viable
and effective drugs to prevent or treat DOX-induced cardiotoxicity (DIC). Vericiguat is widely …