T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …

The blockade of immune checkpoint receptors has made great strides in the treatment of
major cancers, including melanoma, Hodgkin's lymphoma, renal, and lung cancer. However …

The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer
progression in primary and metastatic brain malignancies. The unique properties of this …

Immunotherapy holds tremendous promise for improving cancer treatment. To administer
radiotherapy with immunotherapy has been shown to improve immune responses and can …

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although
chronic inflammation has been described as one of the hallmarks of cancer, acute …

The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Lysosome-mediated autophagy and caspase-dependent apoptosis are dynamic processes
that maintain cellular homeostasis, ensuring cell health and functionality. The intricate …