It has long been appreciated that the Gram-negative outer membrane acts as a permeability
barrier, but recent studies have uncovered a more expansive and versatile role for the outer …

We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …

Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to
their restrictive penetration barrier. BamA, which inserts proteins into the outer membrane, is …

The current need for novel antibiotics is especially acute for drug-resistant Gram-negative
pathogens,. These microorganisms have a highly restrictive permeability barrier, which limits …

Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …

Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …

NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces
superoxide (O2•−), a key reactive oxygen species (ROS) that is essential in innate and …

Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan
layer are crucial for the maintenance of cellular integrity and enable survival in challenging …

There is an urgent need for new antibiotics against Gram-negative pathogens that are
resistant to carbapenem and third-generation cephalosporins, against which antibiotics of …