Aptamer-functionalized nanoparticles in targeted delivery and cancer therapy

Z Fu, J Xiang - International Journal of Molecular Sciences, 2020 - mdpi.com
Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …

Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery

M Narwade, A Shaikh, KR Gajbhiye, P Kesharwani… - Biomaterials …, 2023 - Springer
The non-specificity of standard anticancer therapies has profound detrimental
consequences in clinical treatment. Therapeutic specificity can be precisely achieved using …

Aptamer-functionalized nanomaterials for biological applications

Q Ren, L Ga, Z Lu, J Ai, T Wang - Materials Chemistry Frontiers, 2020 - pubs.rsc.org
Aptamers have attracted the attention of many researchers because of their high stability,
high affinity and high selectivity. Over the past decades, considerable intensive exploration …

[HTML][HTML] Aptamer-drug conjugates: New probes for imaging and targeted therapy

P Liu, L Ga, G Aodeng, Y Wang, J Ai - Biosensors and Bioelectronics: X, 2022 - Elsevier
Since the discovery of aptamer, aptamer has become an exciting and promising diagnostic
and therapeutic tool because of its excellent targeting selectivity, high potential affinity …

Cetuximab-conjugated PLGA nanoparticles as a prospective targeting therapeutics for non-small cell lung cancer

L Kumari, I Ehsan, A Mondal, A Al Hoque… - Journal of Drug …, 2023 - Taylor & Francis
Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers diagnosed
worldwide, yet managing it is still challenging. The epidermal growth factor receptor (EGFR) …

J591 functionalized paclitaxel-loaded PLGA nanoparticles successfully inhibited PSMA overexpressing LNCaP cells

I Ehsan, L Kumari, R Sen, A Al Hoque… - Journal of Drug Delivery …, 2022 - Elsevier
To evaluate the chemotherapeutic efficacy of J591 fabricated poly (d, l)-lactic-co-glycolic
acid (PLGA) nanoparticles containing paclitaxel (Ab-PTX-NP) in vitro in PSMA (prostate …

ΔPSap4# 5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation

A Al Hoque, D Dutta, B Paul, L Kumari, I Ehsan… - Cancer …, 2023 - Springer
Prostate cancer (PCa) is one of the fatal illnesses among males globally. PCa-treatment
does not include radiotherapy. Chemotherapy eventually causes drug resistance, disease …

Fabrication of carboxymethyl chitosan nanoparticles to deliver paclitaxel for melanoma treatment

AS Moghaddam, HA Khonakdar, E Sarikhani… - …, 2020 - Wiley Online Library
In the present study, the effectiveness of paclitaxel nanocrystals (PTX NCs) encapsulated in
carboxymethyl chitosan (CMCS) nanoparticles (CMCS− PTX NPs) as an anticancer drug is …

Application of aptamer functionalized nanomaterials in targeting therapeutics of typical tumors

X Yin, Z He, W Ge, Z Zhao - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Cancer is a major cause of human death all over the world. Traditional cancer treatments
include surgery, radiotherapy, chemotherapy, immunotherapy, and hormone therapy …

Inhibitory potential of iRGD peptide-conjugated garcinol-loaded biodegradable nanoparticles in rat colorectal carcinoma

B Paul, RH Gaonkar, D Dutta, R Dasi, B Mukherjee… - Biomaterials …, 2022 - Elsevier
Targeted drug delivery has become attention in chemotherapy during the last decade. The
principle of chemotherapy seeks maximum effect to the desired site and the minimum impact …