Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives

A Vaiserman, D Krasnienkov - Frontiers in genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Biological Versus Chronological Aging: JACC Focus Seminar

MR Hamczyk, RM Nevado, A Barettino, V Fuster… - Journal of the American …, 2020 - jacc.org
Aging is the main risk factor for vascular disease and ensuing cardiovascular and
cerebrovascular events, the leading causes of death worldwide. In a progressively aging …

Myocardial interstitial fibrosis in heart failure: biological and translational perspectives

A González, EB Schelbert, J Díez, J Butler - Journal of the American …, 2018 - jacc.org
Myocardial interstitial fibrosis contributes to left ventricular dysfunction leading to the
development of heart failure. Basic research has provided abundant evidence for the …

Progression of Early Subclinical Atherosclerosis (PESA) Study: JACC Focus Seminar 7/8

B Ibanez, A Fernández-Ortiz, L Fernández-Friera… - Journal of the American …, 2021 - jacc.org
Atherosclerosis starts early in life and progresses silently for decades. Considering
atherosclerosis as a “systemic disease” invites the use of noninvasive methodologies to …

[HTML][HTML] Evidence and perspectives of cell senescence in neurodegenerative diseases

Z Si, L Sun, X Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

Telomere length measurement by qPCR–Summary of critical factors and recommendations for assay design

J Lin, DL Smith, K Esteves, S Drury - Psychoneuroendocrinology, 2019 - Elsevier
Research in the last decade has explored the length of telomeres, the protective ends of
eukaryotic chromosomes, as a biomarker for the cumulative effects of environmental …

Newborn telomere length predicts later life telomere length: Tracking telomere length from birth to child-and adulthood

DS Martens, C Van Der Stukken, C Derom, E Thiery… - …, 2021 - thelancet.com
Background Telomere length (TL) is considered a biological marker of aging and may
indicate age-related disease susceptibility. Adults and children show a fixed ranking and …

Effect of physical activity, smoking, and sleep on telomere length: a systematic review of observational and intervention studies

R Barragán, C Ortega-Azorín, JV Sorli… - Journal of clinical …, 2021 - mdpi.com
Aging is a risk factor for several pathologies, restricting one's health span, and promoting
chronic diseases (eg, cardiovascular and neurodegenerative diseases), as well as cancer …

[HTML][HTML] Telomere length and brain aging: A systematic review and meta-analysis

P Gampawar, R Schmidt, H Schmidt - Ageing Research Reviews, 2022 - Elsevier
The current evidence on the association of leukocyte telomere length (LTL) with age-related
structural and cognitive changes in the brain is mixed. Herein conforming to PRISMA 2020 …

Leukocyte telomere length in children born following blastocyst-stage embryo transfer

C Wang, Y Gu, J Zhou, J Zang, X Ling, H Li, L Hu… - Nature medicine, 2022 - nature.com
Perinatal and childhood adverse outcomes associated with assisted reproductive
technology (ART) has been reported, but it remains unknown whether the initial leukocyte …