The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The viral outbreak started in late 2019 and rapidly became a …

Alterations in viral fitness cannot be inferred from only mutagenesis studies of an isolated
viral protein. To-date, no systematic analysis has been performed to identify mutations that …

Abstract SARS-CoV-2 papain-like protease is considered as an important potential target for
anti-SARS-CoV-2 drug discovery due to its crucial roles in viral spread and innate immunity …

Taking advantage of the uniquely constricted active site of SARS-CoV-2 Nsp14
methyltransferase, we have designed bisubstrate inhibitors interacting with the SAM and …

As the new year of 2020 approaches, an acute respiratory disease quietly caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus …

Previous studies suggest that berberine, an isoquinoline alkaloid, has antiviral potential and
is a possible therapeutic candidate against SARS-CoV-2. The molecular underpinnings of …

The urgent need for SARS-CoV-2 controls has led to a reassessment of approaches to
identify and develop natural product inhibitors of zoonotic, highly virulent, and rapidly …

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has spread all over the world, creating a devastating socio-economic impact …

A recent study showed that patients with coronavirus disease 2019 (COVID-19) have
gastrointestinal symptoms and intestinal flora dysbiosis. Yeast probiotics shape the gut …