[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry

F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

Noncoding RNA: RNA regulatory networks in cancer

JJ Chan, Y Tay - International journal of molecular sciences, 2018 - mdpi.com
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This
largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and …

Reexamining assumptions about miRNA-guided gene silencing

A Kilikevicius, G Meister, DR Corey - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …

Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: a comprehensive review

A Ismail, HA El-Mahdy, AI Abulsoud… - International Journal of …, 2023 - Elsevier
Breast cancer (BC) is the most common cancer in women and poses a serious threat to their
health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment …

An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer

D Fathi, MS Elballal, AE Elesawy, AI Abulsoud… - Life Sciences, 2023 - Elsevier
Gastric cancer (GC) is 4th in incidence and mortality rates globally. Several genetic and
epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression …

miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

HA El-Mahdy, AM Mohamadin, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …

A review of the biological role of miRNAs in prostate cancer suppression and progression

AS Doghish, A Ismail, HA El-Mahdy, MA Elkady… - International journal of …, 2022 - Elsevier
Prostate cancer (PC) is the third-leading cause of cancer-related deaths worldwide.
Although the current treatment strategies are progressing rapidly, PC is still representing a …

miRNAs as Cornerstones in Chronic Lymphocytic Leukemia Pathogenesis and Therapeutic Resistance–An emphasis on the interaction of signaling pathways

AS Doghish, AI Abulsoud, SS Elshaer… - … -Research and Practice, 2023 - Elsevier
Chronic lymphocytic leukemia (CLL) accounts for the vast majority of cases of leukemia.
Patients of advanced age are more likely to develop the condition, which has a highly varied …

TransmiR v2. 0: an updated transcription factor-microRNA regulation database

Z Tong, Q Cui, J Wang, Y Zhou - Nucleic acids research, 2019 - academic.oup.com
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and
play vital roles in various biological processes. It has been reported that aberrant regulation …