Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

K Suzuki, K Hatzikotoulas, L Southam, HJ Taylor, X Yin… - Nature, 2024 - nature.com
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …

The complete and fully-phased diploid genome of a male Han Chinese

C Yang, Y Zhou, Y Song, D Wu, Y Zeng, L Nie, P Liu… - Cell Research, 2023 - nature.com
Since the release of the complete human genome, the priority of human genomic study has
now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased …

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

K Suryamohan, D Diwanji, EW Stawiski… - Communications …, 2021 - nature.com
COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The
viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) …

Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases

A Otsuki, M Yamamoto - Archives of pharmacal research, 2020 - Springer
Cellular detoxication is essential for health because it provides protection against various
chemicals and xenobiotics. The KEAP1–NRF2 system is important for cellular defense …

jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population

S Tadaka, E Hishinuma, S Komaki… - Nucleic acids …, 2021 - academic.oup.com
Abstract In the Tohoku Medical Megabank project, genome and omics analyses of
participants in two cohort studies were performed. A part of the data is available at the …

Biobanking as a tool for genomic research: from allele frequencies to cross-ancestry association studies

TE Lazareva, YA Barbitoff, AI Changalidis… - Journal of Personalized …, 2022 - mdpi.com
In recent years, great advances have been made in the field of collection, storage, and
analysis of biological samples. Large collections of samples, biobanks, have been …

Reconstruction of the personal information from human genome reads in gut metagenome sequencing data

Y Tomofuji, K Sonehara, T Kishikawa, Y Maeda… - Nature …, 2023 - nature.com
Human DNA present in faecal samples can result in a small number of human reads in gut
shotgun metagenomic sequencing data. However, it is presently unclear how much …

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility

EW Stawiski, D Diwanji, K Suryamohan, R Gupta… - BioRxiv, 2020 - biorxiv.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus
disease (COVID-19) that has resulted in a global pandemic. It is a highly contagious positive …

jMorp: Japanese Multi-Omics Reference Panel update report 2023

S Tadaka, J Kawashima, E Hishinuma… - Nucleic Acids …, 2024 - academic.oup.com
Modern medicine is increasingly focused on personalized medicine, and multi-omics data is
crucial in understanding biological phenomena and disease mechanisms. Each ethnic …

CEP128 is involved in spermatogenesis in humans and mice

X Zhang, L Wang, Y Ma, Y Wang, H Liu, M Liu… - Nature …, 2022 - nature.com
Centrosomal proteins are necessary components of the centrosome, a conserved eukaryotic
organelle essential to the reproductive process. However, few centrosomal proteins have …