Wnt/β-catenin alterations are prominent in human malignancies. In non–small cell lung
cancer (NSCLC), β-catenin and APC mutations are uncommon, but Wnt signaling is …

Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

Cancer metastasis consists of a sequential series of events, and the epithelial–
mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) are recognized …

The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

Tumor metastasis involves a series of biological steps during which the tumor cells acquire
the ability to invade surrounding tissues and survive outside the original tumor site. During …

Introduction The importance of the tumor microenvironment in breast cancer has been
increasingly recognized. Critical molecular changes in the tumor stroma accompanying …

Aberrant activation of the Wnt pathway is implicated in driving the formation of various
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …