The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ)
of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in …

Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that
now spans 35 years of research. While all neurotrophins share considerable overlap in …

Vesicular pathways coupling the neuromuscular junction with the motor neuron soma are
essential for neuronal function and survival. To characterize the organelles responsible for …

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an
unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α …

Neurotrophin signaling is essential for normal nervous system development and adult
function. Neurotrophins are secreted proteins that signal via interacting with two …

During neuronal development, neurotrophins are essential factors that promote survival,
differentiation and myelination of neurons. The trophic signals are relayed to the cells via …

Although identified almost 20 years ago, the precise physiological role of the p75
neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …