Significant experimental, computational, and theoretical work has identified rich structure
within the coordinated activity of interconnected neural populations. An emerging challenge …

The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …

Dense reconstruction of synaptic connectivity requires high-resolution electron microscopy
images of entire brains and tools to efficiently trace neuronal wires across the volume. To …

Understanding the neurobiological underpinnings of emotion relies on objective readouts of
the emotional state of an individual, which remains a major challenge especially in animal …

In order to localize the neural circuits involved in generating behaviors, it is necessary to
assign activity onto anatomical maps of the nervous system. Using brain registration across …

High-resolution serial-section electron microscopy (ssEM) makes it possible to investigate
the dense meshwork of axons, dendrites, and synapses that form neuronal circuits …

The internal brain dynamics that link sensation and action are arguably better studied during
natural animal behaviors. Here, we report on a novel volume imaging and 3D tracking …

Tissue-clearing techniques are powerful tools for biological research and pathological
diagnosis. Here, we describe advanced clear, unobstructed brain imaging cocktails and …

Understanding brain-wide neuronal dynamics requires a detailed map of the underlying
circuit architecture. We built an interactive cellular-resolution atlas of the zebrafish brain at 6 …

Organism-level systems biology aims to identify, analyze, control and design cellular circuits
in organisms. Many experimental and computational approaches have been developed …