Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Multicellular organisms depend on physical cell–cell interactions to control physiological
processes such as tissue formation, neurotransmission and immune response. These …

Herpesviruses assemble large enveloped particles that are difficult to characterize
structurally due to their size, fragility and complex multilayered proteome with partially …

Defining protein–protein interactions (PPIs) in their native environment is crucial to
understanding protein structure and function. Cross-linking–mass spectrometry (XL-MS) has …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

Protein-protein interactions govern most cellular pathways and processes, and multiple
technologies have emerged to systematically map them. Assessing the error of interaction …

Within eukaryotic cells, translation is regulated independent of transcription, enabling
nuanced, localized, and rapid responses to stimuli. Neurons respond transcriptionally and …

Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

Cross-linking mass spectrometry has become an established technology to provide
structural information on the topology and dynamics of protein complexes. Readily …

Elucidating protein–protein interaction (PPI) networks and their structural features within
cells is central to understanding fundamental biology and associations of cell phenotypes …