Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

Cancer phenotypes, referred to as hallmarks of cancer, are acquired by dysregulation of
biochemical networks, in addition to genetic and epigenetic alterations. For the last decade …

Different cancer cell lines can have varying responses to the same perturbations or stressful
conditions. Cancer cells that have DNA damage checkpoint-related mutations are often …

The logical formalism is well adapted to model large cellular networks, in particular when
detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative …

Computational biological models have proven to be an invaluable tool for understanding
and predicting the behaviour of many biological systems. While it may not be too …

In Alzheimer's disease (AD), molecular changes are observed not only in patients' neurons
but also in peripheral cells, such as blood lymphocytes. These include changes in the level …

With the steady advance of in-silico biological experimentation, model construction and
simulation becomes a ubiquitous tool to understand and predict the behaviour of many …

Cells are constantly challenged by intrinsic and extrinsic signals. DNA damage denotes a
serious threat to cellular survival due to its extensive destroy to genomic integrity …

Computational biological models are indispensable tools for in silico hypothesis testing. But
with the increasing complexity of biological systems, traditional simulators become inefficient …

The bio-cell cycle is controlled by a complex biochemical network of signaling pathways.
Modeling such challenging networks accurately is imperative for the understanding of their …