Hyperuricemia and its related diseases: mechanisms and advances in therapy

L Du, Y Zong, H Li, Q Wang, L Xie, B Yang… - … and Targeted Therapy, 2024 - nature.com
Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

Emerging tools and best practices for studying gut microbial community metabolism

C Noecker, PJ Turnbaugh - Nature Metabolism, 2024 - nature.com
The human gut microbiome vastly extends the set of metabolic reactions catalysed by our
own cells, with far-reaching consequences for host health and disease. However, our …

A widely distributed gene cluster compensates for uricase loss in hominids

Y Liu, JB Jarman, YS Low, HE Augustijn, S Huang… - Cell, 2023 - cell.com
Approximately 15% of US adults have circulating levels of uric acid above its solubility limit,
which is causally linked to the disease gout. In most mammals, uric acid elimination is …

Emerging urate-lowering drugs and pharmacologic treatment strategies for gout: a narrative review

R Terkeltaub - Drugs, 2023 - Springer
Hyperuricemia with consequent monosodium urate crystal deposition leads to gout,
characterized by painful, incapacitating inflammatory arthritis flares that are also associated …

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Z Ma, T Zuo, N Frey, AY Rangrez - Signal Transduction and Targeted …, 2024 - nature.com
The human microbiome is a complex and dynamic system that plays important roles in
human health and disease. However, there remain limitations and theoretical gaps in our …

Exploring the multifaceted nexus of uric acid and health: a review of recent studies on diverse diseases

M Kuwabara, T Fukuuchi, Y Aoki, E Mizuta, M Ouchi… - Biomolecules, 2023 - mdpi.com
The prevalence of patients with hyperuricemia or gout is increasing worldwide.
Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors …

Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia

YX Xu, LD Liu, JY Zhu, SS Zhu, BQ Ye, JL Yang… - Cell Host & Microbe, 2024 - cell.com
Hyperuricemia induces inflammatory arthritis and accelerates the progression of renal and
cardiovascular diseases. Gut microbiota has been linked to the development of …

[HTML][HTML] Effects of oxidized fish oil diet supplemented with tea polyphenols on intestinal health and liver metabolism of spotted sea bass (Lateolabrax maculatus)

H Lin, S Zhou, X Li, Y Liu, W Luo, Y Zhao, Z Huang… - Aquaculture …, 2024 - Elsevier
In this study, the effects of oxidized fish oil diet supplemented with tea polyphenols (TP) on
the intestinal health and liver metabolism of spotted sea bass (Lateolabrax maculatus) were …

Gut microecology: effective targets for natural products to modulate uric acid metabolism

H Wang, Y Zheng, M Yang, L Wang, Y Xu… - Frontiers in …, 2024 - frontiersin.org
Gut microecology, the complex community consisting of microorganisms and their
microenvironments in the gastrointestinal tract, plays a vital role in maintaining overall health …

Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury

CJ Anderson, L Boeckaerts, P Chin, JB Cardas… - Cell Host & Microbe, 2024 - cell.com
Cytotoxic chemotherapies have devastating side effects, particularly within the
gastrointestinal tract. Gastrointestinal toxicity includes the death and damage of the …