The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan
receptors because their ligands were unknown. They are now known to contain functional …

Wnts are evolutionarily conserved signaling proteins with essential roles in development
and disease that have often been thought to spread between cells and signal at a distance …

Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the
morphogenesis and body patterning during the development of metazoan species. In recent …

A fundamental goal in the organogenesis field is to understand how cells organize into
tubular shapes. Toward this aim, we have established the hydro-vascular organ in the sea …

The skin of the nematode Caenorhabditis elegans is composed of a simple epidermal
epithelium and overlying cuticle. The skin encloses the animal and plays central roles in …

Cell-cell interactions shape cellular function and ultimately organismal phenotype.
Interacting cells can sense their mutual distance using combinations of ligand-receptor …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

Animals consume a wide variety of food sources to adapt to different environments.
However, the genetic mechanisms underlying the acquisition of evolutionarily novel feeding …

Odontoblasts, cementoblasts, ameloblasts, and osteoblasts all form mineralized tissues in
the craniofacial complex, and all these cell types exhibit active Wnt signaling during …