Abstract NAD (P) H-dependent electron-transfer (ET) systems require three functional
components: a flavin-containing NAD (P) H-dehydrogenase, one-electron carrier and metal …

The general requirement for conformational sampling in biological electron transfer
reactions catalysed by multi‐domain redox systems has been emphasized in recent years …

Mechanisms that regulate the nitric oxide synthase enzymes (NOS) are of interest in biology
and medicine. Although NOS catalysis relies on domain motions, and is activated by …

Protein domain motion is often implicated in biological electron transfer, but the general
significance of motion is not clear. Motion has been implicated in the transfer of electrons …

Protein domain dynamics and electron transfer chemistry are often associated, but real‐time
analysis of domain motion in enzyme‐catalysed reactions and the elucidation of mechanistic …

Nitric oxide (NO) plays diverse roles in mammalian physiology. It is involved in blood
pressure regulation, neurotransmission, and immune response, and is generated through …

NADPH-cytochrome P450 reductase is a multi-domain redox enzyme which is a key
component of the P450 mono-oxygenase drug-metabolizing system. We report studies of …

Biological electron transfer is a fundamentally important reaction. Despite the apparent
simplicity of these reactions (in that no bonds are made or broken), their experimental …

How the dynamics of proteins assist catalysis is a contemporary issue in enzymology. In
particular, this holds true for membrane‐bound enzymes, where multiple structural …

This perspective reviews single molecule and ensemble fluorescence spectroscopy studies
of the three tissue specific nitric oxide synthase (NOS) isoenzymes and the related diflavin …