Blood GFAP as an emerging biomarker in brain and spinal cord disorders

A Abdelhak, M Foschi, S Abu-Rumeileh… - Nature Reviews …, 2022 - nature.com
Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …

The impact of the gut microbiome on extra-intestinal autoimmune diseases

E Miyauchi, C Shimokawa, A Steimle… - Nature Reviews …, 2023 - nature.com
The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS

C Walton, R King, L Rechtman, W Kaye… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Background: High-quality epidemiologic data worldwide are needed to improve our
understanding of disease risk, support health policy to meet the diverse needs of people …

[HTML][HTML] Guts imbalance imbalances the brain: a review of gut microbiota association with neurological and psychiatric disorders

L Mitrea, SA Nemeş, K Szabo, BE Teleky… - Frontiers in …, 2022 - frontiersin.org
In the last ten years, there has been a growing interest regarding the relationship between
gut microbiota, brain, and neurological-associated affections. As multiple preclinical and …

Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

EJ Lim, YC Ahn, ES Jang, SW Lee, SH Lee… - Journal of translational …, 2020 - Springer
Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has been
emerging as a significant health issue worldwide. This study aimed to systemically assess …

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

VL Feigin, E Nichols, T Alam, MS Bannick… - The Lancet …, 2019 - thelancet.com
Background Neurological disorders are increasingly recognised as major causes of death
and disability worldwide. The aim of this analysis from the Global Burden of Diseases …

Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review

A Oliva Ramirez, A Keenan, O Kalau, E Worthington… - BMC neurology, 2021 - Springer
Background Multiple sclerosis (MS) is a chronic, demyelinating disease of the central
nervous system that results in progressive and irreversible disability. Fatigue is one of the …

Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Racial and ethnic disparities in multiple sclerosis prevalence

AM Langer-Gould, EG Gonzales, JB Smith, BH Li… - Neurology, 2022 - AAN Enterprises
Background and Objectives The goal of this work was to determine whether the prevalence
of multiple sclerosis (MS) varies by race and ethnicity. Methods We conducted a …

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

S Werneburg, J Jung, RB Kunjamma, SK Ha… - Immunity, 2020 - cell.com
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous
system. While work has focused on myelin and axon loss in MS, less is known about …