LRRK2 is a relatively common genetic risk factor for Parkinson's disease (PD), with six
coding variants known to cause familial PD. Non-coding variation at the same locus is also …

Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of
immune and central nervous system cell types. Despite extensive investigation into the …

Parkinson's disease (PD) as a progressive neurodegenerative disorder arises from multiple
genetic and environmental factors. However, underlying pathological mechanisms remain …

Understanding medium spiny neuron (MSN) physiology is essential to understand motor
impairments in Parkinson's disease (PD) given the architecture of the basal ganglia. Here …

Neuronal cultures are a prominent experimental tool to understand complex functional
organization in neuronal assemblies. However, neurons grown on flat surfaces exhibit a …

Atrazine (ATZ) is one of the most used herbicides in the US and a known endocrine
disruptor. ATZ is frequently detected in drinking water, especially in Midwestern regions of …

Neuronal cultures are one of the most important experimental models in modern
interdisciplinary neuroscience, allowing to investigate in a control environment the …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to
Parkinson's disease, where the G2019S variant has been shown to contribute uniquely to …

Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia
and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B …

Background: Gait impairments are common in Parkinson's disease (PD). The pathological
mechanisms are complex and not thoroughly elucidated, thus quantitative and objective …