Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody
mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of …

Human sterile α motif and HD domain-containing protein 1 (SAMHD1), originally described
as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) …

Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …

Somatic hypermutation (SHM) produces point mutations in immunoglobulin (Ig) genes in B
cells when uracils created by the activation-induced deaminase are processed in a …

SAMHD1 is a host triphosphohydrolase that degrades intracellular deoxynucleoside
triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents …

Secondary Ig diversification in B cells requires the deliberate introduction of DNA damage
into the Ig genes by the enzyme activation-induced cytidine deaminase (AID) and the error …

Aicardi‐Goutières syndrome (AGS) is a progressive genetic encephalopathy caused by
pathogenic mutations in genes controlling cellular anti‐viral responses and nucleic acid …

Sterile alpha motif and histidine‐aspartic acid domain‐containing protein 1 (SAMHD 1), a
dNTP triphosphohydrolase, regulates the levels of cellular dNTP s through their hydrolysis …

Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of
genomic information within cells. The balance of the dNTP pool involves several cellular …

Background GDSL esterase/lipases (GELPs) play important roles in plant growth,
development, and response to biotic and abiotic stresses. Presently, an extensive and in …