Osteoarthritis (OA) is a highly prevalent and disabling condition that affects over 7% of
people globally (528 million people). Prevalence levels are even higher in countries with …

Maintenance of genomic integrity is critical for the perpetuation of all forms of life including
humans. Living organisms are constantly exposed to stress from internal metabolic …

Health-related quality of life is an important issue in the treatment of breast cancer and
health-state utility values are essential for cost–utility analysis. A literature review was …

Aim Quality of life weights (utilities) are an important input in economic evaluation and
evidence suggests that there can be important differences between countries. This study …

Background Existing reports of utility values for metastatic non-small cell lung cancer
(NSCLC) vary quite widely and are not all suitable for use in submissions in the UK. The aim …

Background: Obesity and knee osteoarthritis are among the most frequent chronic
conditions affecting Americans aged 50 to 84 years. Objective: To estimate quality-adjusted …

Health technology assessment agencies often prefer that utilities used to calculate quality-
adjusted life years in cost-utility analyses (CUAs) are derived using standardized methods …

OBJECTIVE: Prophylactic bilateral salpingo-oophorectomy is advised for women with BRCA
mutations, but there are adverse consequences of premature menopause. The majority of …

Cost-utility models are increasingly used in many countries to establish whether the cost of a
new intervention can be justified in terms of health benefits. Health-state utility (HSU) …

Purpose. Potentially debilitating, osteonecrosis of the jaw (ONJ) is an emerging complication
of bisphosphonates. However, its effect on quality of life (QoL) is unknown. We determined …