A comparative review of chemotherapy-induced peripheral neuropathy in in vivo and in vitro models
S Eldridge, L Guo, J Hamre III - Toxicologic pathology, 2020 - journals.sagepub.com
Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect caused by
several classes of widely used anticancer therapeutics. Chemotherapy-induced peripheral …
several classes of widely used anticancer therapeutics. Chemotherapy-induced peripheral …
Pathogenesis of platinum-induced peripheral neurotoxicity: Insights from preclinical studies
One of the most relevant dose-limiting adverse effects of platinum drugs is the development
of a sensory peripheral neuropathy that highly impairs the patients' quality of life. Nowadays …
of a sensory peripheral neuropathy that highly impairs the patients' quality of life. Nowadays …
Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by the
presence of intracellular aggregates of tau protein and neuronal loss leading to cognitive …
presence of intracellular aggregates of tau protein and neuronal loss leading to cognitive …
Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies
KC Chua, N El‐Haj, J Priotti… - Basic & clinical …, 2022 - Wiley Online Library
Chemotherapy‐induced peripheral neuropathy (CIPN) is a common dose‐limiting toxicity
that affects 30%–40% of patients undergoing cancer treatment. Although multiple …
that affects 30%–40% of patients undergoing cancer treatment. Although multiple …
Human induced pluripotent stem cell derived sensory neurons are sensitive to the neurotoxic effects of paclitaxel
Chemotherapy‐induced peripheral neuropathy (CIPN) is a dose‐limiting adverse event
associated with treatment with paclitaxel and other chemotherapeutic agents. The …
associated with treatment with paclitaxel and other chemotherapeutic agents. The …
Bridging the translational gap in chemotherapy-induced peripheral neuropathy with iPSC-based modeling
C Mortensen, NE Andersen, TB Stage - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy-induced peripheral neuropathy (CIPN) remains a clinical
challenge with a considerable impact on the effective treatment of cancers and quality of life …
challenge with a considerable impact on the effective treatment of cancers and quality of life …
Mechanisms of peripheral neurotoxicity associated with four chemotherapy drugs using human induced pluripotent stem cell-derived peripheral neurons
M Wang, J Wang, AYP Tsui, Z Li, Y Zhang, Q Zhao… - Toxicology in Vitro, 2021 - Elsevier
The awareness of the long-term toxicities of cancer survivors after chemotherapy treatment
has been gradually strengthened as the population of cancer survivors grows. Generally …
has been gradually strengthened as the population of cancer survivors grows. Generally …
iPSCs as a groundbreaking tool for the study of adverse drug reactions: A new avenue for personalized therapy
P Rispoli, T Scandiuzzi Piovesan… - WIREs Mechanisms …, 2024 - Wiley Online Library
Induced pluripotent stem cells (iPSCs), obtained by reprogramming different somatic cell
types, represent a promising tool for the study of drug toxicities, especially in the context of …
types, represent a promising tool for the study of drug toxicities, especially in the context of …
Developing novel computational prediction models for assessing chemical-induced neurotoxicity using naïve Bayes classifier technique
H Zhang, J Mao, HZ Qi, HZ Xie, C Shen, CT Liu… - Food and Chemical …, 2020 - Elsevier
Abstract Development of reliable and efficient alternative in vivo methods for evaluation of
the chemicals with potential neurotoxicity is an urgent need in the early stages of drug …
the chemicals with potential neurotoxicity is an urgent need in the early stages of drug …
[HTML][HTML] Induced pluripotent stem cells for therapy personalization in pediatric patients: focus on drug-induced adverse events
E Genova, F Cavion, M Lucafò, L De Leo… - World journal of stem …, 2019 - ncbi.nlm.nih.gov
Adverse drug reactions (ADRs) are major clinical problems, particularly in special
populations such as pediatric patients. Indeed, ADRs may be caused by a plethora of …
populations such as pediatric patients. Indeed, ADRs may be caused by a plethora of …