Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …

Axonal degeneration is an active process that differs from neuronal death, and it is the
hallmark of many disorders affecting the central and peripheral nervous system. Starting …

SARM1 is a central executioner of programmed axon death, and this role requires intrinsic
NAD (P) ase or related enzyme activity. A complete absence of SARM1 robustly blocks axon …

Simple Summary Cancer is a leading cause of death worldwide, with most of these deaths
being the result of tumor metastasis (spread of cancer cells from the primary site). The sterile …

Background Sterile alpha and toll interleukin receptor motif-containing protein 1 (SARM1)
are primarily expressed in the mammalian nervous system, with their presence in neurons …

A series of mass mortalities (wash-ups) of marine life were documented along England's
north east coastline with peaks in September and October 2021, coincident with a …

Programmed axon death (PAD) is an evolutionary-conserved path of axon destruction
initiated by injury and disease. Two proteins are known to profoundly influence axonal …

The functioning of the nervous system rests on connections between neurons and their
synaptic targets. Often these targets can be a great distance from the neuron, which leaves …