Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion
of immature myeloid cells in the bone marrow (BM) and peripheral blood (PB) resulting in …

Acute myeloid leukemias (AML) comprise a wide array of different entities, which have in
common a rapid expansion of myeloid blast cells leading to displacement of normal …

Patients with acute myeloid leukemia (AML) often achieve remission after allogeneic
hematopoietic cell transplantation (allo-HCT) but subsequently die of relapse driven by …

Purpose: The stromal and immune bone marrow (BM) landscape is emerging as a crucial
determinant for acute myeloid leukemia (AML). Regulatory T cells (Treg) are enriched in the …

The field of immuno-oncology is now at the forefront of cancer care and is rapidly evolving.
The immune checkpoint blockade has been demonstrated to restore antitumor responses in …

Simple Summary Despite high rates of remission obtained with conventional chemotherapy,
the persistence of leukemic cells after treatments, eventually exiting in disease relapse …

Adult bone marrow (BM) hematopoietic stem cells (HSCs) are maintained in a quiescent
state and sustain the continuous production of all types of blood cells. HSCs reside in a …

Background. Cluster of differentiation 86 (CD86), also known as B7‐2, is a molecule
expressed on antigen‐presenting cells that provides the costimulatory signals required for T …

The progression of acute myeloid leukaemia (AML) is influenced by the immune
microenvironment in the bone marrow and dysregulated intracellular competing …

Polyphenols are one of the largest plant-derived natural product and they play an important
role in plants' defense as well as in human health and disease. A number of them are …